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KMID : 0370220200640050377
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Yakhak Hoeji
2020 Volume.64 No. 5 p.377 ~ p.386
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Suppressive Effects of Premature Citrus unshiu Extract on Dimethylnitrosamine-induced Hepatic Fibrosis in Mice
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Han Sang-Chul
Yun Ji-Hyun
Yoon Weon-Jong
Yoon Seon-A
Kang Hee-Kyoung
Yoo Eun-Sook
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Abstract
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Hepatic fibrosis is a wound healing process of the liver, which is characterized by overproduction andaccumulation of extracellular matrix. Hepatic fibrosis occurs when chronic inflammation causes a deposition of scar tissue.
Dimethylnitrosamine (DMN) is a potent liver toxin that can lead to fibrosis of the liver. DMN causes massive hepatocytedamage, cell death by necrosis or apoptosis and liver tissue distribution. Citrus unshiu, which is known to contain severalflavonoids, has pharmacological effects on anti-oxidative, anti-cancer, anti-microviral and anti-inflammation activity. Therefore,we investigated the effect of premature C. unshiu and fermented premature C. unshiu extract on DMN-induced hepaticfibrosis mouse model. Here, we show that administration of premature C. unshiu and fermented premature C. unshiureduces the generation of triglyceride, alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde(MDA) and cytochrome P450 2E1 (CYP2E1) in mouse serum. Also, the extract reduced the mRNA expression ofglutathione S-transferases (GSTs), Heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and increasedinflammatory factors such as IL-6, COX-2 and iNOS. These results suggest that premature C. unshiu has anti-hepaticfibrosis activity by regulating metabolic detoxification pathways such as cytochrome P450s and GSTs.
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KEYWORD
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hepatic fibrosis, dimethylnitrosamine, Citrus unshiu, cytochrome P450s, glutathione S-transferases
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